Forskolin [66575-29-9]

Catalog number: HY-15371_10mg
Brand: MedChem Express
Packing: 10 mg
Other sizes: Other sizes available
Price: € 99.00
Expected delivery time: 10 days

Product specifications for - Forskolin [66575-29-9]

Product group: Chemicals
Category: Other
CAS No.: 66575-29-9
Purity: >98%
Molecular Formula: C22H34O7
Molecular weight: 410.50
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Forskolin(Colforsin) is a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory and adenylate cyclase activating properties. IC50 Value: 0.5 uM (EC50) Target: Adenylate cyclase in vitro: Forskolin (10 microM) rapidly increased cAMP levels in bovine thyroid slices both in the absence and presence of a phosphodiesterase inhibitor. The effect of TSH (50 mU/ml) on cAMP levels was additive or greater than additive to that of forskolin [1]. Fsk treatment of MT-2 and Kit 225 T-cells inhibited IL-2-induced Stat5a/b tyrosine and serine phosphorylation, nuclear translocation, and DNA binding activity. Fsk treatment also uncoupled IL-2 induced association of the IL-2Rbeta and gammac chain, consequently blocking Jak3 activation [2]. in vivo: Low concentrations of forskolin (0.1-1.0 microM), which significantly elevated cyclic AMP levels, did not increase lipolysis, whereas similar increases in cyclic AMP levels due to isoproterenol elevated lipolysis. Forskolin did not inhibit the activation of triacylglycerol lipase by cyclic AMP-dependent protein kinase or the subsequent hydrolysis of triacylglycerol [3]. Colforsin-induced vasodilation was impaired in both +E and -E arteries from PH rats compared with their respective controls. Endothelial removal did not influence colforsin-induced vasodilation in the arteries from control rats, but attenuated it in arteries from PH rats [4]. Clinical trial: N/A
Safety information: 
Additional information: 
Synonyms: HY-15371
Signal Transduct Target Ther. 2021 Feb 28;6(1):91. Read more
Sci Transl Med. 2020 May 6;12(542):eaba0769. Read more
Peptides. 2019 Dec;122:169874. Read more
Orphanet J Rare Dis. 2020 Jun 30;15(1):170. Read more
Nat Metab. 2022 Jan 6. Read more
Jove-J Vis Exp. 2020 Jul 8;(161). Read more
J Neurotrauma. 2021 Feb;38(3):353-364. Read more
J Neurosci Methods. 2022 Jan 15;366:109404. Read more
J Lipid Res. 2018 Feb;59(2):330-338. Read more
J Exp Clin Cancer Res. 2019 Sep 13;38(1):404. Read more