Gefitinib-d3 [1173976-40-3]

MedChem Express

Gefitinib-d3 [1173976-40-3]

10

1173976-40-3

C22H21D3ClFN4O3

449.92

Gefitinib-d3 (ZD1839-d3) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

N(C=1C2=C(C=C(OC([2H])([2H])[2H])C(OCCCN3CCOCC3)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

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