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IDH-305

HY-104036
MedChem Express
CAS Number1628805-46-8
DownloadMSDS
Product group Chemicals
Estimated Purity98.75
Molecular Weight490.45
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Overview

  • Supplier
    MedChem Express
  • Product Name
    IDH-305 [1628805-46-8]
  • Delivery Days Customer
    10
  • CAS Number
    1628805-46-8
  • Certification
    Research Use Only
  • Estimated Purity
    98.75
  • Molecular Formula
    C23H22F4N6O2
  • Molecular Weight
    490.45
  • Scientific Description
    IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT ( IC 50 = 27 nM (IDH1 R132H ), 28 nM (IDH1 R132C ), 6.14 microM (IDH1 WT )) [1] [2] .
  • SMILES
    O=C1OC[C@H]([C@@H](F)C)N1C2=NC(N[C@H](C3=CC(C)=C(C4=CC(C(F)(F)F)=NC=C4)C=N3)C)=NC=C2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200