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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
Latrunculin B [76343-94-7]
Catalog number:
AG-CN2-0031-M001
Brand:
AdipoGen Life Sciences
Packing:
1 mg
Other sizes:
Other size available
Price:
€ 200.00
Expected delivery time:
7 days
Quantity:
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General
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Chemical Structure
Chemical Structure...
Chemical Structure
Chemical Structure
Product specifications for - Latrunculin B [76343-94-7]
Overview:
Product group:
Chemicals
Category:
Other
CAS No.:
76343-94-7
Properties:
Purity:
>96% (HPLC)
Molecular Formula:
C20H29NO5S
Molecular weight:
395.5
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352200
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Depolymerizes actin filaments (F-actin). Less potent than Latrunculin A (Prod. No. AG-CN2-0027 http://www.adipogen.com/ag-cn2-0027/latrunculin-a.html ). May have fewer unwanted effects than latrunculin A and may be preferred for short-term studies. Acts via a different mechanism than cytochalasins. - Chemical. CAS: 76343-94-7. Formula: C20H29NO5S. MW: 395.5. Isolated from Latrunculia magnifica. Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Depolymerizes actin filaments (F-actin). Less potent than Latrunculin A (Prod. No. AG-CN2-0027 http://www.adipogen.com/ag-cn2-0027/latrunculin-a.html ). May have fewer unwanted effects than latrunculin A and may be preferred for short-term studies. Acts via a different mechanism than cytochalasins.
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous, Warning
Additional information:
Synonyms:
AG-CN2-0031-M001
Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells: I. Spector, et al.; Science 219, 493 (1983)
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Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice: G. Schatten, et al.; Exp. Cell Res. 166, 191 (1986)
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Inhibition of actin polymerization by latrunculin: A: M. Coue, et al.; FEBS Lett. 213, 316 (1987)
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Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D: I. Spector, et al.; Cell Motil. Cytoskeleton 13, 127 (1989)
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Effects of cytochalasin D and latrunculin B on mechanical properties of cells: T. Wakatsuki, et al.; J. Cell. Sci. 114, 1025 (2001)
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RNAi screening identifies the armadillo repeat-containing kinesins responsible for microtubule-dependent nuclear positioning in Physcomitrella patens: T. Miki, et al.; Plant Cell Physiol. 56, 737 (2015)
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Evidence that an unconventional actin can provide essential F-actin function and that a surveillance system monitors F-actin integrity in Chlamydomonas: M. Onishi, et al.; Genetics 202, 977 (2016)
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