McMMAF [863971-19-1]

Catalog number: HY-15578_1mg
Brand: MedChem Express
Packing: 1 mg
Other sizes: Other sizes available
Price: € 238.00
Expected delivery time: 10 days

Product specifications for - McMMAF [863971-19-1]

Product group: Chemicals
Category: Other
CAS No.: 863971-19-1
Purity: >98%
Molecular Formula: C49H76N6O11
Molecular weight: 925.16
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Mc-MMAF is a protective group-conjugated MMAF. MMAF is a more potent drug than Monomethyl auristatin E (MMAE), but is charged and relatively membrane-impermeable, is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. Target: MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.
Safety information: 
Additional information: 
Synonyms: HY-15578
J Control Release. 2020 Nov 10;327:186-197. Read more
Anal Chem. 2022 Feb 1. Read more
Patent. US20160304621A1. Read more
Patent. US10087260B2. Read more