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NFAT Inhibitor is a selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). In Vitro: NFAT Inhibitor is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts. NFAT Inhibitor (100 uM) that effectively inhibits NFAT1-calcineurin binding and NFAT1 dephosphorylation, does not inhibit calcineurin phosphatase activity toward the RII phosphopeptide. NFAT Inhibitor selectively inhibits NFAT activation without disrupting other calcineurin-dependent pathways[1]. NFAT Inhibitor attenuates NFAT-dependant protein expression in immune cells. NFAT activity regulates proinflammatory secretion and is attenuated by NFAT Inhibitor in murine microglia cultures[2].
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