NFAT Inhibitor [249537-73-3]

Catalog number: HY-P1026_1mg
Brand: MedChem Express
Packing: 1 mg
Other sizes: Other sizes available
Price: € 131.00
Expected delivery time: 10 days

Product specifications for - NFAT Inhibitor [249537-73-3]

Product group: Chemicals
Category: Other
CAS No.: 249537-73-3
Purity: >98%
Molecular Formula: C75H120N20O22S
Molecular weight: 1685.94
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: NFAT Inhibitor is a selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). In Vitro: NFAT Inhibitor is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts. NFAT Inhibitor (100 uM) that effectively inhibits NFAT1-calcineurin binding and NFAT1 dephosphorylation, does not inhibit calcineurin phosphatase activity toward the RII phosphopeptide. NFAT Inhibitor selectively inhibits NFAT activation without disrupting other calcineurin-dependent pathways[1]. NFAT Inhibitor attenuates NFAT-dependant protein expression in immune cells. NFAT activity regulates proinflammatory secretion and is attenuated by NFAT Inhibitor in murine microglia cultures[2].
Safety information: 
Additional information: 
Synonyms: HY-P1026
Tohoku J Exp Med. 2021;253(4):249-259. Read more
Sci Signal. 2018 Oct 16;11(552). pii: eaao5150. Read more
J Immunother Cancer. 2021 Jul;9(7):e002840. Read more
Arthritis Rheumatol. 2019 Aug;71(8):1252-1264. Read more
Cell Rep. 2021, 108959. Read more