Nigericin . sodium salt [28... | AG-CN2-0020-M005

Chemical Structure

Chemical Structure...

Product specifications for - Nigericin . sodium salt [28643-80-3]

Overview:
Product group:	Chemicals
Category:	Antibiotics
CAS No.:	28643-80-3

Properties:
Purity:	>98%
Molecular Formula:	C40H67O11 . Na
Molecular weight:	724.0 . 23.0
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	51280000
Storage instructions:	2-¦C to 8-¦C, -20-¦C

Scientific information:
Scientific info:	Antibiotic. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator - Chemical. CAS: 28643-80-3. Formula: C40H67O11 . Na. MW: 724.0 . 23.0. Isolated from Streptomyces hygroscopicus. Antibiotic. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator

Scientific information:

Scientific info:

Antibiotic. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator - Chemical. CAS: 28643-80-3. Formula: C40H67O11 . Na. MW: 724.0 . 23.0. Isolated from Streptomyces hygroscopicus. Antibiotic. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator

Safety information:
ADR klasse:	6.1
UN Number:	UN 3462
MSDS:	MSDS
Hazard information:	Danger, Excepted quantity

Additional information:
Synonyms:	AG-CN2-0020-M005

Nigericin, a new crystalline antibiotic from an unidentified streptomyces: R. L. Harned, et al.; Antibiot. Chemother. 1, 594 (1951)

Potassium Ion-dependent hydrolysis of adenosine triphosphate induced by nigericin in mitochondria: S. Estrada-O, et al.; J. Biol. Chem. 242, 2925 (1967)

Teratogenic effects of nigericin, a carboxylic ionophore: G.C. Vedel-Macrander & R.D. Hood; Teratology 33, 47 (1986)

K+/H+-antiporter nigericin arrests DNA synthesis in Ehrlich ascites carcinoma cells: L.B. Margolis, et al.; PNAS 86, 6626 (1989)

IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin: D. Perregaux, et al.; J. Immunol. 149, 1294 (1992)

Antitumor effect of k+/h+-antiporter nigericin on human lung-carcinoma grown in in-vivo-like histocultures: B. Baibakov, et al.; Int. J. Oncol. 3, 1127 (1993)

Nigericin-induced Na+/H+ and K+/H+ exchange in synaptosomes: effect on [3H]GABA release: R. Rodríguez & M. Sitges; Neurochem. Res. 21, 889 (1996)

Activation of interleukin-1beta-converting enzyme by nigericin is independent of apoptosis: N. Watanabe, et al.; Cytokine 10, 645 (1998)

Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes: C.Y. Chu, et al.; J. Cell Biochem. 85, 83 (2002)

The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin: S.A. Hamidinia, et al.; Biochemistry 43, 15956 (2004)

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Nigericin . sodium salt [28643-80-3]

Product specifications for - Nigericin . sodium salt [28643-80-3]

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Nigericin . sodium salt [28643-80-3]

Product specifications for - Nigericin . sodium salt [28643-80-3]