Bio-Connect
Chemical Structure
Chemical Structure
Chemical Structure

Parthenolide [20554-84-1]

Research Use Only
AG-CN2-0455
AdipoGen Life Sciences
CAS Number20554-84-1
Product group Chemicals
Estimated Purity>98%
Molecular Weight248.3
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Parthenolide
  • Delivery Days Customer
    10
  • CAS Number
    20554-84-1
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C15H20O3
  • Molecular Weight
    248.3
  • Scientific Description
    Anticancer and antiangiogenic compound. Induces apoptosis, cell cycle arrest and autophagy in various cancer cell lines. At low concentrations acts as antioxidant reducing oxidative stress generated through the TCR signaling pathway. At high concentration induces O2- and causes oxidative-stress-mediated apoptosis. Potent anti-inflammatory and anti-atherosclerotic agent. NF-kappaB inhibitor by directly targeting IkappaB kinase. Inhibits STAT-mediated anti-apoptotic gene transcription. NLRP3 inflammasome inhibitor. Inhibits ATPase activity of NLRP3 and protease activity of caspase 1. Directly binds the pattern recognition receptor NOD2. Specifically inhibits HDAC1 without affecting other class I/II HDACs. DNA methyltransferase 1 (DNMT1) inhibitor. Induces ubiquitination of MDM2 resulting in the activation of p53 and other MDM2-regulated tumor suppressor proteins. VEGF inhibitor. Reduces the expression of VEGF and its receptors VEGRF1 and 2. Inhibits tubulin carboxypeptidase (TCP) activity. Microtubule-interfering compound, inhibiting cell migration and tubule formation. Anti-leishmanial and anti-trypanosomal agent. Partial TRPA1 agonist. - Chemical. CAS: 20554-84-1. Formula: C15H20O3. MW: 248.3. Isolated from Magnolia grandiflora. Anticancer and antiangiogenic compound. Induces apoptosis, cell cycle arrest and autophagy in various cancer cell lines. At low concentrations acts as antioxidant reducing oxidative stress generated through the TCR signaling pathway. At high concentration induces O2- and causes oxidative-stress-mediated apoptosis. Potent anti-inflammatory and anti-atherosclerotic agent. NF-kappaB inhibitor by directly targeting IkappaB kinase. Inhibits STAT-mediated anti-apoptotic gene transcription. NLRP3 inflammasome inhibitor. Inhibits ATPase activity of NLRP3 and protease activity of caspase 1. Directly binds the pattern recognition receptor NOD2. Specifically inhibits HDAC1 without affecting other class I/II HDACs. DNA methyltransferase 1 (DNMT1) inhibitor. Induces ubiquitination of MDM2 resulting in the activation of p53 and other MDM2-regulated tumor suppressor proteins. VEGF inhibitor. Reduces the expression of VEGF and its receptors VEGRF1 and 2. Inhibits tubulin carboxypeptidase (TCP) activity. Microtubule-interfering compound, inhibiting cell migration and tubule formation. Anti-leishmanial and anti-trypanosomal agent. Partial TRPA1 agonist.
  • SMILES
    C\C1=C/CC[C@@]2(C)O[C@@H]2[C@H]2OC(=O)C(=C)[C@@H]2CC1
  • Storage Instruction
    2°C to 8°C,RT
  • UNSPSC
    12352200

Related products

Chemical Structure
Product group Chemicals
Chemodex
CAS Number92614-59-0
Estimated Purity>90%
Molecular Weight335.38
  • SizePrice
Chemical Structure
Product group Chemicals
Chemodex
CAS Number92614-59-0
Estimated Purity>90%
Molecular Weight335.38
  • SizePrice
Chemical Structure
Product group Chemicals
Chemodex
CAS Number92614-59-0
Estimated Purity>90%
Molecular Weight335.38
  • SizePrice
Chemical Structure
Product group Chemicals
Chemodex
CAS Number14984-39-5
Estimated Purity>98%
Molecular Weight216.12
  • SizePrice
Chemical Structure
Product group Chemicals
Chemodex
CAS Number528-48-3
Estimated Purity>98%
Molecular Weight286.24
  • SizePrice
Chemical Structure
Product group Chemicals
Chemodex
CAS Number14984-39-5
Estimated Purity>98%
Molecular Weight216.12
  • SizePrice
Chemical Structure
Product group Chemicals
Chemodex
CAS Number6556-12-3
Estimated Purity>98%
Molecular Weight194.14
  • SizePrice
Chemical Structure
Product group Chemicals
Chemodex
CAS Number6556-12-3
Estimated Purity>98%
Molecular Weight194.14
  • SizePrice
Chemical Structure
Product group Chemicals
Chemodex
CAS Number16564-43-5
Estimated Purity>97%
Molecular Weight471.61
  • SizePrice
Chemical Structure
Product group Chemicals
Chemodex
CAS Number16564-43-5
Estimated Purity>97%
Molecular Weight471.61
  • SizePrice