Pevonedistat [905579-51-3]

Catalog number: HY-70062_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: Also available in other sizes.
Price: € 939.00
Expected delivery time: 10 days

Product specifications for - Pevonedistat [905579-51-3]

Product group: Chemicals
Category: Other
CAS No.: 905579-51-3
Purity: >98%
Molecular Formula: C21H25N5O4S
Molecular weight: 443.52
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM). IC50 value: 4.7 nM Target: NAE At much higher concentrations, MLN 4924 inhibits the related enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE) with IC50 values of 1.5 and 8.2 uM, respectively. At 0.3 uM, MLN 4924 has been shown to disrupt CRL-mediated protein turnover leading to apoptosis in HCT-116 cells by deregulating S-phase DNA synthesis. In vivo, 30-60 mg/kg MLN 4924 dose-dependently suppresses the growth of human tumor xenografts in mice.
Safety information: 
Counteraction of the antiviral factor tetherin by HIV-1 Group O', Frank Kirchhoff . Ulm University. 13-01-2017. Read more
Radiosensitization of Human Colorectal Cancer Cells by MLN4924: An Inhibitor of NEDD8-Activating Enzyme. ', Juefeng Wan . Technol Cancer Res Treat. 2016 Aug;15(4):527-34. Read more
Lys29-linkage of ASK1 by Skp1−Cullin 1−Fbxo21 ubiquitin ligase complex is required for antiviral innate response', Yu Z. Elife. 2016 Apr 11;5. pii: e14087. Read more
Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation', Cheng M. Oncotarget. 2016 Jun 14;7(24):35643-35654. Read more
Circadian clock components RORα and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells', Zhang S. Oncotarget. 2016 Oct 4;7(40):66087-66099. Read more
MLN4924 suppresses the BRCA1 complex and synergizes with PARP inhibition in NSCLC cells.', Zong-Pei Guo. Biochem Biophys Res Commun. 2017 Jan 29;483(1):223-229. Read more
Nedd8 modification of Cullin-5 regulates lipopolysaccharide-induced acute lung injury', Zhu Z. Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L104-L114. Read more
TET1 inhibits cell proliferation by inducing RASSF5 expression', Li BT. Oncotarget. 2017 Sep 23;8(49):86395-86409. Read more
High-Content Monitoring of Drug Effects in a 3D Spheroid Model', Mittler F. Front Oncol. 2017 Dec 11;7:293. Read more