Pexidartinib [1029044-16-3]

Catalog number: HY-16749_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: 5 mg
10 mM
10 mg
50 mg
200 mg
Price: € 217.00
Expected delivery time: 10 days

Product specifications for - Pexidartinib [1029044-16-3]

Product group: Chemicals
Category: Other
CAS No.: 1029044-16-3
Purity: >98%
Molecular Formula: C20H15ClF3N5
Molecular weight: 417.81
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Pexidartinib(PLX-3397) is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. IC50 value: 28/16 nM(Fms/Kit) Target: multikinase inhibitor Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis.
Safety information: