PIM-447 (dihydrochloride) [1820565-69-2]

Catalog number: HY-19322B_10mg
Brand: MedChem Express
Packing: 10 mg
Other sizes: Other sizes available
Price: € 648.00
Expected delivery time: 10 days

Product specifications for - PIM-447 (dihydrochloride) [1820565-69-2]

Product group: Chemicals
Category: Other
CAS No.: 1820565-69-2
Purity: >98%
Molecular Formula: C24H25Cl2F3N4O
Molecular weight: 513.38
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase. target: pan-PIM inhibitor [2] [3] In vitro: PIM447 is cytotoxic for myeloma cells due to cell cycle disruption and induction of apoptosis mediated by a decrease in phospho-Bad (Ser112) and c-Myc levels and the inhibition of mTORC1 pathway. PIM447 also inhibits in vitro osteoclast formation and resorption, downregulates key molecules involved in these processes and partially disrupts the F-actin ring, while increasing osteoblast activity and mineralization.[1] In vivo: PIM447 significantly reduces the tumor burden and preventes tumor-associated bone loss in a disseminated murine model of human myeloma.[1]
Safety information: 
Additional information: 
Synonyms: HY-19322B
Mol Cancer Ther. 2018 Apr;17(4):849-857. Read more
J Pathol. 2020 Sep;252(1):65-76. Read more