Prexasertib (dihydrochloride)

MedChem Express

Prexasertib (dihydrochloride) [1234015-54-3]

10

1234015-54-3

Research Use Only

99.41

C18H21Cl2N7O2

438.31

Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K i of 0.9 nM and an IC 50 of 50 =8 nM) and RSK1 (IC 50 =9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis . Prexasertib dihydrochloride shows potent anti-tumor activity [1] [2] .

NCCCOC(C=CC=C1OC)=C1C2=CC(NC3=NC=C(C#N)N=C3)=NN2.[H]Cl.[H]Cl

2°C to 8°C

12352200