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(rel)-AR234960

HY-120006A
MedChem Express
CAS Number1408311-94-3
Product group Chemicals
Estimated Purity99.42
Molecular Weight555.62
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (rel)-AR234960 [1408311-94-3]
  • Delivery Days Customer
    9
  • CAS Number
    1408311-94-3
  • Certification
    Research Use Only
  • Estimated Purity
    99.42
  • Molecular Formula
    C27H30FN5O5S
  • Molecular Weight
    555.62
  • Scientific Description
    (rel)-AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS. (rel)-AR234960 binds to the MAS receptor to activate the downstream ERK1/2 signaling pathway, inducing the expression of connective tissue growth factor (CTGF) and its downstream collagen subtype genes (such as COL1A1, COL3A1). (rel)-AR234960 promotes collagen synthesis in cardiac fibroblasts through the MAS-ERK1/2-CTGF pathway and aggravates extracellular matrix remodeling. (rel)-AR234960s in vitro effect can be blocked by the MAS inverse agonist AR244555 and MEK1 inhibitor. (rel)-AR234960 regulates the expression of cardiac fibrosis-related genes and can be used in the study of heart failure[1][2].
  • SMILES
    O=S(N1C[C@@H](CN2CCN(C3=NC=CC=C3)CC2)[C@H](C4=CC=CC(F)=C4)C1)(C5=CC=C([N+]([O-])=O)C=C5OC)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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