(rel)-AR234960
HY-120006A
CAS Number1408311-94-3
Product group Chemicals
Estimated Purity99.42
Molecular Weight555.62
Overview
- SupplierMedChem Express
- Product Name(rel)-AR234960 [1408311-94-3]
- Delivery Days Customer9
- CAS Number1408311-94-3
- CertificationResearch Use Only
- Estimated Purity99.42
- Molecular FormulaC27H30FN5O5S
- Molecular Weight555.62
- Scientific Description(rel)-AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS. (rel)-AR234960 binds to the MAS receptor to activate the downstream ERK1/2 signaling pathway, inducing the expression of connective tissue growth factor (CTGF) and its downstream collagen subtype genes (such as COL1A1, COL3A1). (rel)-AR234960 promotes collagen synthesis in cardiac fibroblasts through the MAS-ERK1/2-CTGF pathway and aggravates extracellular matrix remodeling. (rel)-AR234960s in vitro effect can be blocked by the MAS inverse agonist AR244555 and MEK1 inhibitor. (rel)-AR234960 regulates the expression of cardiac fibrosis-related genes and can be used in the study of heart failure[1][2].
- SMILESO=S(N1C[C@@H](CN2CCN(C3=NC=CC=C3)CC2)[C@H](C4=CC=CC(F)=C4)C1)(C5=CC=C([N+]([O-])=O)C=C5OC)=O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200