Sceptrin . dihydrochloride... | AG-CN2-0440-C500

Chemical Structure

Chemical Structure...

Product specifications for - Sceptrin . dihydrochloride [79703-25-6]

Overview:
Product group:	Chemicals
Category:	Antibiotics
CAS No.:	79703-25-6

Properties:
Purity:	>97% (HPLC)
Molecular Formula:	C22H24Br2N10O2 . 2HCl
Molecular weight:	620.3 . 72.9
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	51280000
Storage instructions:	2-¦C to 8-¦C, -20-¦C

Scientific information:
Scientific info:	Antibiotic. Inhibits the growth of several Gram-positive and Gram-negative bacteria. Binds to MreB inducing disruption of the bacterial cell wall. Competitive inhibitor of muscarinic acetylcholine receptors (mAChR). Cell motility inhibitor by specifically blocking contractility of the cell. Direct binding with monomeric actin disrupts the polymerization of actin into microfilaments necessary for cellular mechanical processes. - Chemical. CAS: 79703-25-6. Formula: C22H24Br2N10O2 . 2HCl. MW: 620.3 . 72.9. Isolated from the sponge Agelas nakamurai. Antibiotic. Inhibits the growth of several Gram-positive and Gram-negative bacteria. Binds to MreB inducing disruption of the bacterial cell wall. Competitive inhibitor of muscarinic acetylcholine receptors (mAChR). Cell motility inhibitor by specifically blocking contractility of the cell. Direct binding with monomeric actin disrupts the polymerization of actin into microfilaments necessary for cellular mechanical processes.

Scientific information:

Scientific info:

Antibiotic. Inhibits the growth of several Gram-positive and Gram-negative bacteria. Binds to MreB inducing disruption of the bacterial cell wall. Competitive inhibitor of muscarinic acetylcholine receptors (mAChR). Cell motility inhibitor by specifically blocking contractility of the cell. Direct binding with monomeric actin disrupts the polymerization of actin into microfilaments necessary for cellular mechanical processes. - Chemical. CAS: 79703-25-6. Formula: C22H24Br2N10O2 . 2HCl. MW: 620.3 . 72.9. Isolated from the sponge Agelas nakamurai. Antibiotic. Inhibits the growth of several Gram-positive and Gram-negative bacteria. Binds to MreB inducing disruption of the bacterial cell wall. Competitive inhibitor of muscarinic acetylcholine receptors (mAChR). Cell motility inhibitor by specifically blocking contractility of the cell. Direct binding with monomeric actin disrupts the polymerization of actin into microfilaments necessary for cellular mechanical processes.

Safety information:
MSDS:	MSDS
Hazard information:	Non-hazardous, Warning

Additional information:
Synonyms:	AG-CN2-0440-C500

Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges: R. Rosa, et al.; Experientia 48, 885 (1992)

A study on the mechanism of action of sceptrin, an antimicrobial agent isolated from the South Pacific sponge Agelas mauritiana: V.S. Bernan, et al.; J. Antimicrob. Chemother. 32, 539 (1993)

Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol: A.D. Rodriguez, et al.; JACS 130, 7256 (2008)

Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines: A. Cipres, et al.; ACS Chem. Biol. 5, 195 (2010)

Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence: Z. Ma, et al.; Science 346, 219 (2014)

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Sceptrin . dihydrochloride [79703-25-6]

Product specifications for - Sceptrin . dihydrochloride [79703-25-6]

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Sceptrin . dihydrochloride [79703-25-6]

Product specifications for - Sceptrin . dihydrochloride [79703-25-6]