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Swinholide A [95927-67-6]

Catalog number: AG-CN2-0035-C010
Brand: AdipoGen Life Sciences
Packing: 10 ug
Other sizes: Other size available
Price: € 103.00
Expected delivery time: 7 days
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Chemical Structure
Chemical Structure...

Product specifications for - Swinholide A [95927-67-6]

Overview: 
Product group: Chemicals
Category: Other
CAS No.: 95927-67-6
Properties: 
Purity: >97% (HPLC)
Molecular Formula: C78H132O20
Molecular weight: 1389.9
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: Cell permeable dimeric dilactone macrolide. Cytotoxic compound. Specific actin filament (F-actin) inhibitor. Disrupts the actin cytoskeleton by sequestering actin dimers and rapidly severing actin filaments (F-actin). Depolymerizes actin filaments (F-actin). Antifungal. Apoptosis inducer. Alterates the actin cytoskeleton of GH4 cells and inhibits insulin-increased prolactin gene transcription. - Chemical. CAS: 95927-67-6. Formula: C78H132O20. MW: 1389.9. Isolated from marine sponge Theonella swinhoei. Cell permeable dimeric dilactone macrolide. Cytotoxic compound. Specific actin filament (F-actin) inhibitor. Disrupts the actin cytoskeleton by sequestering actin dimers and rapidly severing actin filaments (F-actin). Depolymerizes actin filaments (F-actin). Antifungal. Apoptosis inducer. Alterates the actin cytoskeleton of GH4 cells and inhibits insulin-increased prolactin gene transcription.
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-CN2-0035-C010
Marine natural products. XXIII. Three new cytotoxic dimeric macrolides, swinholides B and C and isoswinholide A, congeners of swinholide A, from the Okinawan marine sponge Theonella swinhoei: M. Kobayashi, et al.; Chem. Pharm. Bull. (Tokyo) 38, 2960 (1990) Read more
Marine natural products. XXXI. Structure-activity correlation of a potent cytotoxic dimeric macrolide swinholide A, from the Okinawan marine sponge Theonella swinhoei, and its isomers: M. Kobayashi, et al.; Chem. Pharm. Bull. (Tokyo) 42, 19 (1994) Read more
Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments: M.R. Bubb, et al.; J. Biol. Chem. 270, 3463 (1995) Read more
Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts: C.A. Bewley, et al.; Experientia 52, 716 (1996) Read more
Use of the F-actin-binding drugs, misakinolide A and swinholide A: M.R. Bubb & I. Spector; Methods Enzymol. 298, 26 (1998) Read more
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem. 123, 571 (1998) Read more
Actin-binding marine macrolides: total synthesis and biological importance: K.S. Yeung & I. Paterson; Angew. Chem. Int. Ed. Engl. 41, 4632 (2002) (Review) Read more
Structural basis of swinholide A binding to actin: V.A. Klenchin, et al.; Chem. Biol. 12, 287 (2005) Read more
Actin cytoskeleton derangement induces apoptosis in renal ischemia/reperfusion: M. Genesca, et al.; Apoptosis 11, 563 (2006) Read more
Insulin-increased prolactin gene expression requires actin treadmilling: potential role for p21 activated kinase: F.M. Stanley; Endocrinol. 148, 5874 (2007) Read more
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