Z-VAD-FMK (Cell permeable) [187389-52-2]

AdipoGen Life Sciences

Z-VAD-FMK (Cell permeable)

10

187389-52-2

Research Use Only

>95%

C22H30FN3O7

467.5

Cell permeable, non-selective broad-spectrum caspase inhibitor [1, 3, 7, 8]. Binds irreversibly to the catalytic site of caspase proteases [1]. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability [1]. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction [2-4, 6, 9]. Decreases proteasome activity [5]. Potent inhibitor of caspase-1 activation in NLRP3/NALP3-induced cells [10]. Used in apoptosis and inflammasome studies. - Chemical. CAS: 187389-52-2 and 634911-81-2. Formula: C22H30FN3O7. MW: 467.5. Synthetic. Cell permeable, non-selective broad-spectrum caspase inhibitor. Binds irreversibly to the catalytic site of caspase proteases. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Potent inhibitor of caspase-1 activation in NLRP3/NALP3-induced cells. Used in apoptosis and inflammasome studies.

[H][C@](NC(=O)OCC1=CC=CC=C1)(C(C)C)C(=O)N[C@@H](C)C(=O)NC(CC(=O)OC)C(=O)CF

-20°C,2°C to 8°C

51202000