Z-VAD(OMe)-FMK [187389-52-2]

Catalog number: HY-16658_10mg
Brand: MedChem Express
Packing: 10 mg
Other sizes: 1 mg
5 mg
10 mM
Price: € 328.00
Expected delivery time: 10 days

Product specifications for - Z-VAD(OMe)-FMK [187389-52-2]

Product group: Chemicals
Category: Other
CAS No.: 187389-52-2
Purity: >98%
Molecular Formula: C22H30FN3O7
Molecular weight: 467.49
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Z-VAD(OMe)-FMK is a cell-permeable, pan-caspase inhibitor. IC50 & Target: pan-caspase[1] In Vitro: Z-VAD(OMe)-FMK is a broad-spectrum caspase inhibitor, has been shown to inhibit the intracellular activation of caspase-like proteases. The injection of Z-VAD(OMe)-FMK suppresses the caspase-3 activity in lung tissues, and significantly decreases the number of terminal dUTP nick-end labeling-positive cells[1]. Z-VAD(OMe)-FMK is administered intraperitoneally at 1 hour before and 6 hours after SAH. Expression of caspase-3 and positive TUNEL is examined as markers for apoptosis. Z-VAD(OMe)-FMK suppresses TUNEL and caspase-3 staining in endothelial cells, decreases caspase-3 activation, reduces BBB permeability, relieves vasospasm, abolishes brain edema, and improves neurological outcome[2]. Z-VAD(OMe)-FMK is a cell-permeable caspase inhibitor, efficiently blocks cell death induced by SMN deficiency[3]. In Vivo: The survival rate of mice is prolonged significantly by the injection of Z-VAD(OMe)-FMK. All mice succumbed to LPS within 30 hours. By contrast, the mice treated with Z-VAD(OMe)-FMK survive significantly longer and 27% of the mice survived more than 7 days[1].
Safety information: 
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A Picorna-like Virus Suppresses the N-end Rule Pathway to Inhibit Apoptosis', Wang Z. Elife. 2017 Dec 12;6. pii: e30590. Read more
Structural Modification of Natural Product Tanshinone I Leading to Discovery of Novel Nitrogen-Enriched Derivatives with Enhanced Anticancer Profile and Improved Drug-Like Properties', Ding C. J Med Chem. 2018 Jan 2. Read more
Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer', Liang W. Oncotarget. 2017 Nov 17;8(65):109094-109106. Read more
Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells', Seo N. Nat Commun. 2018 Jan 30;9(1):435. Read more