CHET3

MedChem Express

CHET3

9

Research Use Only

C21H21N5O3S

423.49

CHET3 is a sex-selective activator with potent analgesic activity. CHET3 was discovered to be a highly selective omnidirectional modulator of TASK-3-containing K2P channels, including TASK-3 homologues and TASK-3/TASK-1 heterologues. CHET3 exhibited significant analgesic effects in multiple acute and chronic pain models in mice, which could be abolished by pharmacological means or genetic knockout of TASK-3. CHET3 is able to functionally modulate the membrane excitability of specific small sensory neurons, which supports its analgesic effects on thermal hypersensitivity and mechanical hyperalgesia in chronic pain[1].

CC(C=C1)=CC=C1SCC(NC(NC(NC2=CC=C(OCCO3)C3=C2)=N)=N4)=CC4=O

12352200