Chlorpromazine (hydrochloride)

MedChem Express

Chlorpromazine (hydrochloride)

9

69-09-0

Research Use Only

99.90

C17H20Cl2N2S

355.33

Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 microM; concentration-dependent) and HERG potassium channels (IC50=21.6 microM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis[1][2][3][4][5].

CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13.Cl

2°C to 8°C

12352200