CHMFL-ABL/KIT-155

MedChem Express

CHMFL-ABL/KIT-155 [2081093-21-0]

10

2081093-21-0

C33H38F3N5O3

609.68

CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor ( IC 50 s of 46 nM and 75 nM, respectively), and it also presents significant inhibitory activities to BLK ( IC 50 =81 nM), CSF1R ( IC 50 =227 nM), DDR1 ( IC 50 =116 nM), DDR2 ( IC 50 =325 nM), LCK ( IC 50 =12 nM) and PDGFRbeta ( IC 50 =80 nM) kinases. CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) arrests cell cycle progression and induces apoptosis [1] .

O=C(N1CCC(OC2=CC(NC(C3=CC=C(CN4CCN(C)CC4)C(C(F)(F)F)=C3)=O)=CC=C2C)CC1)C5=CC=C(C)N=C5

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