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CHMP4B Antibody

Research Use Only
CSB-PA887976ESR1HU
Cusabio
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCHMP4B
Price on request
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More than 130 suppliers
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Overview

  • Supplier
    Cusabio
  • Product Name
    CHMP4B Antibody
  • Delivery Days Customer
    20
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID128866
  • Target name
    CHMP4B
  • Target description
    charged multivesicular body protein 4B
  • Target synonyms
    C20orf178; charged multivesicular body protein 4b; CHMP4A; chromatin modifying protein 4B; chromatin-modifying protein 4b; CTPP3; CTRCT31; dJ553F4.4; hSnf7-2; hVps32-2; Shax1; SNF7; SNF7 homolog associated with Alix 1; Snf7 homologue associated with Alix 1; SNF7-2; vacuolar protein-sorting-associated protein 32-2; Vps32-2; VPS32B
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9H444
  • Protein Name
    Charged multivesicular body protein 4b
  • Scientific Description
    Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203