CIB-1476

MedChem Express

CIB-1476

9

Research Use Only

C28H28N2O6S

520.60

CIB-1476 is a caspase-1 inhibitor. CIB-1476 can exert lasting anti-inflammatory effects by inhibiting IL-1beta production, NF-kappaB activation, and GSDMD-mediated pyroptosis induced by the NLRP3 inflammasome. CIB-1476 can reduce joint swelling in models of arthritis in mice[1].

O=C(N(C1=C2C=C(C=C1)OC)C(OCC3=CC=CC=C3)=O)[C@]42C=C[C@@H](C[C@H]4C(OC(C)(C)C)=O)N=C=S

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