CID-2011756

Bioss Antibodies

CID-2011756 [638156-11-3]

16

Research Use Only

98.0

CID-2011756 is a cell-active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate cancer cells. IC50 Value: 10+/-0.7 uM (cellular inhibition of phospho-Ser916-PKD1 activity) [1] Target: PKD CID 2011756, has pan-PKD inhibitory effects (PKD2 IC50 = 0.6+/-0.1 uM; PKD3 IC50 = 0.7+/-0.2 uM) with similar, albeit not identical, potencies which may be expected for an ATP competitive inhibitor. CID 2011756 was the most potent of the inhibitors with a cellular EC50 of 10+/-0.7 uM (n = 3), an EC50 value comparable to that of our previously described benzoxoloazepinolone.

-20°C

51202000