CIITA Antibody

Cusabio

CIITA Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

CIITA

class II major histocompatibility complex transactivator

C2TA; CIITAIV; MHC class II transactivator; MHC class II transactivator type I; MHC class II transactivator type III; MHC2TA; NLR family, acid domain containing; NLRA; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing

Rabbit

IgG

MHC class II transactivator

Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at Ser-37 and other histones (in vitro). Steimle V., Cell 75:135-146(1993). Al-Kandari W., J. Mol. Biol. 369:1175-1187(2007). Al-Kandari W., Mol. Immunol. 44:311-321(2007). Croager E.J., Biochim. Biophys. Acta 1353:231-235(1997).

Human, Mouse, Rat

-20°C or -80°C

12352203