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ProductsBack/Cinnamtannin B-1 [88082-60-4]
Chemical Structure
Chemical Structure
Chemical Structure

Cinnamtannin B-1 [88082-60-4]

Research Use Only
AG-CN2-0428
AdipoGen Life Sciences
CAS Number88082-60-4
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight864.7
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Cinnamtannin B-1 [88082-60-4]
  • Delivery Days Customer
    10
  • CAS Number
    88082-60-4
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C45H36O18
  • Molecular Weight
    864.7
  • Scientific Description
    A-Type proanthocyanidine. Selective cytotoxic agent [1]. Potent antioxidant [2, 4, 8, 9]. Lipid peroxidation inhibitor [2]. Antidiabetic, with similar effects to insulin activity in adipogenesis [3]. Free radical scavenger [4]. Antithrombotic. Inhibits platelet aggregation [5, 6, 8]. Apoptosis inhibitor [7, 12]. Reduces intracellular Ca(2+) overload and ROS production [8, 10]. Antibacterial [9]. Cyclooxygenase-2 (COX-2) inhibitor in vitro [11]. LDL oxidation inhibitor [13]. - Chemical. CAS: 88082-60-4. Formula: C45H36O18. MW: 864.7. Isolated from Laurus nobilis L. A-Type proanthocyanidine. Selective cytotoxic agent. Potent antioxidant. Lipid peroxidation inhibitor. Antidiabetic, with similar effects to insulin activity in adipogenesis. Free radical scavenger. Antithrombotic. Inhibits platelet aggregation. Apoptosis inhibitor. Reduces intracellular Ca(2+) overload and ROS production. Antibacterial. Cyclooxygenase-2 (COX-2) inhibitor in vitro. LDL oxidation inhibitor.
  • SMILES
    O[C@@H]1CC2=C(O)C=C(O)C([C@@H]3[C@@H](O)[C@H](OC4=C5[C@@H]6[C@@H](O)[C@@](OC7=CC(O)=CC(O)=C67)(OC5=CC(O)=C34)C3=CC(O)=C(O)C=C3)C3=CC=C(O)C(O)=C3)=C2O[C@@H]1C1=CC(O)=C(O)C=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents: Y. Kashiwada, et al.; J. Nat. Prod. 55, 1033 (1992)
  • Antioxidant activity of tannin components from Vaccinium vitis-idaea L: K.Y. Ho, et al.; J. Pharm. Pharmacol. 51, 1075 (1999)
  • Cinnamtannin B1 activity on adipocytes formation: M. Taher, et al.; Med. J. Malaysia 59, 97 (2004)
  • Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity: G.K. Jayaprakasha, et al.; J. Agric. Food Chem. 54, 1672 (2006)
  • Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets: N. Ben Amor, et al.; J. Med. Chem. 50, 3937 (2007)
  • Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients: A. Bouaziz, et al.; Arch. Biochem. Biophys. 457, 235 (2007)
  • Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets: A. Bouaziz, et al.; Apoptosis 12, 489 (2007)
  • Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor: J.J. López, et al.; Life Sci. 82, 977 (2008)
  • Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties : T.O. Idowu, et al.; Phytochemistry 71, 2092 (2010)
  • Effect of cinnamtannin B-1 on cholecystokinin-8-evoked responses in mouse pancreatic acinar cells: R. Rivera-Barreno, et al.; Clin. Exp. Pharmacol. Physiol. 37, 980 (2010)