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ProductsBack/CK2 Inhibitor 10 [1361229-76-6]
Chemical Structure
Chemical Structure
Chemical Structure

CK2 Inhibitor 10 [1361229-76-6]

Research Use Only
AG-CR1-3626
AdipoGen Life Sciences
CAS Number1361229-76-6
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight354.4 . 9.0
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    CK2 Inhibitor 10 [1361229-76-6]
  • Delivery Days Customer
    10
  • CAS Number
    1361229-76-6
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C18H14N2O4S . 0.5H2O
  • Molecular Weight
    354.4 . 9.0
  • Scientific Description
    Chemical. CAS: 1361229-76-6. Formula: C18H14N2O4S . 0.5H2O. MW: 354.4 . 9.0. Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2alpha=32nM and IC50 CK2alpha=46nM). Potently also inhibits DYRK1B and FLT3. Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis. - Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2alpha=32nM and IC50 CK2alpha=46nM). Potently also inhibits DYRK1B and FLT3. Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.
  • SMILES
    COC1=CC=C(C=C1)C(=O)NC1=NC=C(S1)C1=CC=C(C=C1)C(O)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds: Z. Hou, et al.; J. Med. Chem. 55, 2899 (2012)
  • Phosphoproteomics identifies CK2 as a negative regulator of beige adipocyte thermogenesis and energy expenditure: K. Shinoda, et al.; Cell Metab. 22, 997 (2015)