CL 316,243 [138908-40-4]

AdipoGen Life Sciences

CL 316,243 [138908-40-4]

10

138908-40-4

Research Use Only

>98%

C20H18ClNO7 . 2Na

419.8 . 46.0

Chemical. CAS: 138908-40-4. Formula: C20H18ClNO7 . 2Na. MW: 419.8 . 46.0. Potent and selective beta3-adrenoceptor agonist (EC50=3nM) that is >10,000-fold selective over beta1 and beta2. Antidiabetic and antiobesity agent. Causes a rapid decrease in blood glucose level in mice. Increases brown adipose tissue thermogenesis. Induces functionally active mitochondrial uncoupling protein (UCP) in white fat. Restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice. - Potent and selective beta3-adrenoceptor agonist (EC50=3nM) that is >10,000-fold selective over beta1 and beta2. Antidiabetic and antiobesity agent. Causes a rapid decrease in blood glucose level in mice. Increases brown adipose tissue thermogenesis. Induces functionally active mitochondrial uncoupling protein (UCP) in white fat. Restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice.

ClC1=CC=CC([C@@H](O)CN[C@H](C)CC2=CC=C(OC(C([O-])=O)(C([O-])=O)O3)C3=C2)=C1.[Na+].[Na+]

-20°C,2°C to 8°C

12352200