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Cl-amidine

HY-100574
MedChem Express
CAS Number913723-61-2
Product group Chemicals
Molecular Weight310.78
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Cl-amidine [913723-61-2]
  • Delivery Days Customer
    10
  • CAS Number
    913723-61-2
  • Certification
    Research Use Only
  • Molecular Formula
    C14H19ClN4O2
  • Molecular Weight
    310.78
  • Scientific Description
    Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC 50 values of 0.8 microM, 6.2 microM and 5.9 microM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model [1] [2] [3] [4] [5] .
  • SMILES
    O=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1
  • UNSPSC
    12352200