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Cl-amidine (hydrochloride)

HY-100574A
MedChem Express
CAS Number1373232-26-8
DownloadMSDS
Product group Chemicals
Estimated Purity99.39
Molecular Weight347.246
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Cl-amidine (hydrochloride) [1373232-26-8]
  • Delivery Days Customer
    10
  • CAS Number
    1373232-26-8
  • Certification
    Research Use Only
  • Estimated Purity
    99.39
  • Molecular Formula
    C14H20Cl2N4O2
  • Molecular Weight
    347.246
  • Scientific Description
    Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor, with IC 50 values of 0.8 microM, 6.2 microM and 5.9 microM for PAD1, PAD3, and PAD4, respectively. Cl-amidine hydrochloride induces apoptosis in cancer cells. Cl-amidine hydrochloride induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model [1] [2] [3] [4] [5] .
  • SMILES
    O=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1.[H]Cl
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200