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Cl-amidine (TFA)

HY-100574B
MedChem Express
CAS Number1043444-18-3
Product group Chemicals
Molecular Weight424.80
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Cl-amidine (TFA) [1043444-18-3]
  • Delivery Days Customer
    10
  • CAS Number
    1043444-18-3
  • Molecular Formula
    C16H20ClF3N4O4
  • Molecular Weight
    424.80
  • Scientific Description
    Cl-amidine TFA is an orally active peptidylarginine deminase (PAD) inhibitor, with IC 50 values of 0.8 microM, 6.2 microM and 5.9 microM for PAD1, PAD3, and PAD4, respectively. Cl-amidine TFA induces apoptosis in cancer cells. Cl-amidine TFA induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine TFA prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model [1] [2] [3] [4] [5] .
  • SMILES
    O=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1.O=C(O)C(F)(F)F
  • UNSPSC
    12352200