CLASP1 Antibody

Cusabio

CLASP1 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

CLASP1

cytoplasmic linker associated protein 1

CLIP-associating protein 1; MAST1; multiple asters 1; multiple asters homolog 1; protein Orbit homolog 1

Rabbit

IgG

CLIP-associating protein 1

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Maiato H., Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. Hillier L.W., Nature 434:724-731(2005). Akhmanova A., Cell 104:923-935(2001).

Human

-20°C or -80°C

12352203