Clasto-lactacystin beta-lactone [154226-60-5]

BPS Bioscience

Clasto-lactacystin beta-lactone [154226-60-5]

7

154226-60-5

Research Use Only

2.18 mM

≥98% by HPLC

C10H15NO4

213.2 Da

Clasto-lactacystin beta-lactone, also known as Omuralide and beta-Clastolactacystin, targets ubiquitins. It is an active metabolite of lactacystin which induces differentiation and inhibition of cell cycle progression in several tumor cell lines. The inhibitor irreversibly alkylates subunit X of the 20s proteasome. Inhibition of proteasome peptidase activity results in the accumulation of various ubiquitinated proteins which normally undergo rapid degredation. Therefore, the effects are pleiotropic and largely depend on the expression patter of signaling proteins within the treated cell.

-20°C

12352200