Western blot All lanes: CLK2 antibody at 5ug/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 61, 18, 60 kDa Observed band size: 61 kDa
Western blot All lanes: CLK2 antibody at 5ug/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 61, 18, 60 kDa Observed band size: 61 kDa
CLK2 Antibody
CSB-PA005558ESR1HU
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCLK2
Overview
- SupplierCusabio
- Product NameCLK2 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1196
- Target nameCLK2
- Target descriptionCDC like kinase 2
- Target synonymsCLK kinase; dual specificity protein kinase CLK2
- HostRabbit
- IsotypeIgG
- Protein IDP49760
- Protein NameDual specificity protein kinase CLK2
- Scientific DescriptionDual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203