Western blot analysis of extracts from COLO205 cells and A549 cells, using CLK2 antibody.
Western blot analysis of extracts from COLO205 cells and A549 cells, using CLK2 antibody.
CLK2 Antibody
CSB-PA562044
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetCLK2
Overview
- SupplierCusabio
- Product NameCLK2 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1196
- Target nameCLK2
- Target descriptionCDC like kinase 2
- Target synonymsCLK kinase; dual specificity protein kinase CLK2
- HostRabbit
- IsotypeIgG
- Protein IDP49760
- Protein NameDual specificity protein kinase CLK2
- Scientific DescriptionDual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Hanes J.J., J. Mol. Biol. 244:665-672(1994). Winfield S.L., Genome Res. 7:1020-1026(1997). Lee K., J. Biol. Chem. 271:27299-27303(1996).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203