CLM3

MedChem Express

CLM3

9

Research Use Only

C21H21N5

343.42

CLM3, a pyrazolopyrimidine derivative, is a multiple tyrosine kinase inhibitor. CLM3 shows antiproliferative and proapoptotic activity on endothelial and cancer cells, synergistically enhanced by SN38 (HY-13704). These effects are mainly due to its inhibition of phosphorylation of VEGFR-2 , EGFR and RET tyrosine kinases and their related signaling pathways [1] .

C[C@@H](NC1=C2C(N(CCC3=CC=CC=C3)N=C2)=NC=N1)C4=CC=CC=C4

12352200