CLOCK antibody

GeneTex

CLOCK antibody

9

WB: 1:1000. ChIP assay: 1:10 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ChIP Chromatin ImmunoPrecipitation

Research Use Only

Polyclonal

Unconjugated

Clock

circadian locomotor output cycles kaput

5330400M04Rik; bHLHe; circadian locomoter output cycles protein kaput; KAT13; KAT13D

Rabbit

IgG

Circadian locomoter output cycles protein kaput

ARNTL/2-CLOCK heterodimers activate E-box element (3-CACGTG-5) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. Acetylates primarily histones H3 and H4. Acetylates also a non-histone substrate: its own partner, ARNTL.

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203