Closantel-13C6 [1325559-20-3]

MedChem Express

Closantel-13C6 [1325559-20-3]

10

1325559-20-3

Research Use Only

C16 13C6H14Cl2I2N2O2

669.03

Closantel-13C6 is the 13C6 labeled Closantel. Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 microM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.

N#CC(C(C=C1)=CC=C1Cl)C(C=C2C)=C(C=C2NC([13C]([13CH]=[13C]3I)=[13C]([13C](I)=[13CH]3)O)=O)Cl

12352200