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Clostridium difficile (Toxin A)(253/422), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC040202
Biotium
ReactivityBacteria, Bovine, Mouse
Product group Antibodies
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Overview

  • Supplier
    Biotium
  • Product Name
    Clostridium difficile (Toxin A)(253/422), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    253/422
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP16154
  • Protein Name
    Toxin A
  • Scientific Description
    This MAb reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aeruginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bacteria, Bovine, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203