Clostridium difficile (Toxin A)(253/422), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC040202
ReactivityBacteria, Bovine, Mouse
Product group Antibodies
Overview
- SupplierBiotium
- Product NameClostridium difficile (Toxin A)(253/422), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID253/422
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- HostMouse
- IsotypeIgG1
- Protein IDP16154
- Protein NameToxin A
- Scientific DescriptionThis MAb reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aeruginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBacteria, Bovine, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203