Clozapine N-oxide (dihydrochloride)

MedChem Express

Clozapine N-oxide (dihydrochloride)

10

Research Use Only

99.74

C18H21Cl3N4O

415.74

Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di . Clozapine N-oxide dihydrochloride can cross the blood-brain barrier [1] [2] [3] [4] . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor ( EC 50 =11 nM) agonist [5] [6] .

C[N+]1([O-])CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1.[H]Cl.[H]Cl

2°C to 8°C

12352200