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ProductsBack/CLZ-8 [678158-55-9]
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CLZ-8 [678158-55-9]

Research Use Only
T16030
TargetMol Chemicals
CAS Number678158-55-9
DownloadMSDS
Product group Chemicals
Molecular Weight393.5
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    CLZ-8 [678158-55-9]
  • Delivery Days Customer
    14
  • CAS Number
    678158-55-9
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Mcl1-IN-8
  • Molecular Formula
    C22H23N3O2S
  • Molecular Weight
    393.5
  • Scientific Description
    CLZ-8 (Mcl1-IN-8) is an orally active inhibitor of Mcl-1-PUMA (p53 up-regulated mediator of apoptosis) with radioprotective properties.CLZ-8 ameliorates radiation-induced HUVEC cell damage and reduces apoptosis counts, and inhibits radiation-induced overexpression of PUMA.
  • Shelf life instruction
    3 years
  • SMILES
    OCCN1CCN(CC1)C1=NC(=O)\C(S1)=C\c1ccc(cc1)-c1ccccc1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Liu J, et al. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242.
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