CMLD-2

MedChem Express

CMLD-2 [958843-91-9]

10

958843-91-9

Research Use Only

98.99

C31H31NO6

513.58

CMLD-2, an inhibitor of HuR-ARE interaction , competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs ( K i =350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation [1] [2] .

O=C1C=C(C2=CC=CC=C2)C3=C(OC)C=C(OC)C(C(C4=CC=C(OC)C=C4)CC(N5CCCC5)=O)=C3O1

-20°C,2°C to 8°C

12352200