CNX-500

Biorbyt

CNX-500 [1202758-21-1]

10

1202758-21-1

Research Use Only

C48H68N10O9S

961.18

CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn.

CC(C=N1)=C(NC2=CC(NC(C=C)=O)=CC=C2)N=C1NC3=CC=CC(OCCCNC(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]4[C@@H](NC5=O)[C@@H](N5)CS4)=O)=O)=O)=C3

12352200