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COH34 [906439-72-3]

COH34 [906439-72-3]

Research Use Only
T10859
TargetMol Chemicals
CAS Number906439-72-3
DownloadMSDS
Product group Chemicals
Estimated Purity98.21%
Molecular Weight293.38
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    COH34 [906439-72-3]
  • Delivery Days Customer
    4
  • CAS Number
    906439-72-3
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    COH34
  • Estimated Purity
    98.21%
  • Molecular Formula
    C18H15NOS
  • Molecular Weight
    293.38
  • Scientific Description
    COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 microM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
  • Shelf life instruction
    3 years
  • SMILES
    Cc1ccc(S\N=C\c2c(O)ccc3ccccc23)cc1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Chen SH et al., 2019 Apr, Sci Adv
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