Colistin sulfate (Ph.Eur. Grade) [1264-72-8]

AdipoGen Life Sciences

Colistin sulfate (Ph.Eur. Grade)

10

6.1

1264-72-8

Research Use Only

>77%

Danger,Excepted quantity

2(C52H98N16O13) . 5(H2SO4) (unspec.)

2801.7

Chemical. CAS: 1264-72-8. Formula: 2(C52H98N16O13) . 5(H2SO4) (unspec.). MW: 2801.7. Isolated from Bacillus polymyxa. Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections. - Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.

CCC(C)CCCC(N[C@@H](CCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](CCN)C(N[C@H](C(N[C@@H](CCN)C1=O)=O)CCNC([C@@H](NC([C@@H](NC([C@H](CCN)NC([C@@H](NC([C@H](N1)CC(C)C)=O)CC(C)C)=O)=O)CCN)=O)[C@@H](C)O)=O)=O)=O)=O)=O.O=S(O)(O)=O

2°C to 8°C

UN3462

12352200