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ProductsBack/Colistin sulfate (USP Grade) [1264-72-8]
Chemical Structure
Chemical Structure
Chemical Structure

Colistin sulfate (USP Grade) [1264-72-8]

Research Use Only
AG-CN2-0065
AdipoGen Life Sciences
CAS Number1264-72-8
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Product group Chemicals
Molecular Weight2801.7
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Colistin sulfate (USP Grade) [1264-72-8]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    1264-72-8
  • Certification
    Research Use Only
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    2(C52H98N16O13) . 5(H2SO4) (unspec.)
  • Molecular Weight
    2801.7
  • Scientific Description
    Chemical. CAS: 1264-72-8. Formula: 2(C52H98N16O13) . 5(H2SO4) (unspec.). MW: 2801.7. Isolated from Bacillus polymyxa. Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections. - Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.
  • SMILES
    CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O
  • Storage Instruction
    2°C to 8°C
  • UN Number
    UN 3462
  • UNSPSC
    12352200

References

  • Antimicrobial drugs, microorganisms, and phagocytes: P.J. van den Broek; Rev. Infect. Dis. 11, 213 (1989) (Review)
  • Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria: M.E. Evans, et al.; Ann. Pharmacother. 33, 960 (1999) (Review)
  • The clinical use of colistin in patients with cystic fibrosis: P. Beringer; Curr. Opin. Pulm. Med. 7, 434 (2001) (Review)
  • Update on antimicrobial agents: new indications of older agents: T.R. Pasquale & J.S. Tan; Expert Opin. Pharmacother. 6, 1681 (2005) (Review)
  • Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections: J. Li, et al.; Lancet Infect. Dis. 6, 589 (2006) (Review)
  • Polymyxin B: similarities to and differences from colistin (polymyxin E): A. Kwa, et al.; Expert Rev. Anti. Infect. Ther. 5, 811 (2007) (Review)
  • Colistin in the 21st century: R.L. Nation & J. Li; Curr. Opin. Infect. Dis. 22, 535 (2009) (Review)
  • New information about the polymyxin/colistin class of antibiotics: J. Molina, et al.; Expert Opin. Pharmacother. 10, 2811 (2009) (Review)
  • Colistin: new lessons on an old antibiotic: D. Yahav, et al.; Clin. Microbiol. Infect. 18, 18 (2012) (Review)