Collismycin A [158792-24-6]

TargetMol Chemicals

Collismycin A [158792-24-6]

16

158792-24-6

Chemical

Research Use Only

Collismycin A

C13H13N3O2S

275.33

Collismycin A is a bacterial metabolite from *Streptomyces* with antibacterial, antiproliferative, and neuroprotective properties. It exhibits activity against various bacteria (MICs = 6.25-100 microg/ml) and fungi (MICs = 12.5-100 microg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 microM, respectively) and NIH373 fibroblasts (IC50 = 56.6 microM) but not MDA-MD-231 breast cancer cells (IC50 > 100 microM). Collismycin A forms a complex with Fe(II) and Fe(III) in a 2:1 ratio, with iron ions inhibiting its antiproliferative effect on HeLa cells, an effect not observed with zinc, manganese, copper, or magnesium ions. Additionally, Collismycin A (1 microM) reduces apoptosis in zebrafish larvae brain regions by 44% in a model of neuronal cell death induced by all-trans retinoic acid.

3 years

COc1cc(nc(\C=N\O)c1SC)-c1ccccn1

-20°C

12352200