C5 / C5a antibody [7L11]

GeneTex

Complement C5a antibody [7L11]

9

WB: 1:500 - 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, Neutralisation/Blocking

Research Use Only

Monoclonal

7L11

500 ug/ml

Unconjugated

Hc

hemolytic complement

C5; C5a; complement C5; He; hepatic fibrogenesis 2; Hfib; Hfib2

Rat

IgG2

Complement C5

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model. [provided by RefSeq, Nov 2015]

Mouse

-20°C or -80°C,2°C to 8°C

12352203