Chemical Structure
Chemical Structure
Compound E [209986-17-4]
AG-CR1-0081
Overview
- SupplierAdipoGen Life Sciences
- Product NameCompound E [209986-17-4]
- Delivery Days Customer10
- CAS Number209986-17-4
- CertificationResearch Use Only
- Estimated Purity>98%
- Molecular FormulaC27H24F2N4O3
- Molecular Weight490.5
- Scientific DescriptionCell permeable, potent, selective, non-transition state and non-competitive gamma-secretase inhibitor. Notch processing inhibitor. Only weakly affects presenilinase activity. - Chemical. CAS: 209986-17-4. Formula: C27H24F2N4O3. MW: 490.5. Cell permeable, potent, selective, non-transition state and non-competitive gamma-secretase inhibitor. Notch processing inhibitor. Only weakly affects presenilinase activity.
- SMILESC[C@H](NC(=O)CC1=CC(F)=CC(F)=C1)C(=O)N[C@H]1N=C(C2=CC=CC=C2)C2=C(C=CC=C2)N(C)C1=O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
References
- Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors: D. Seiffert, et al.; J. Biol. Chem. 275, 34086 (2000)
- Presenilin-dependent gamma-secretase activity modulates thymocyte development: P. Doerfler, et al.; PNAS 98, 9312 (2001)
- Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology: D. Beher, et al.; J. Biol. Chem. 276, 45394 (2001)
- gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase: C.Y. Ni, et al.; Science 294, 2179 (2001)
- Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor: K.M. Jung, et al.; J. Biol. Chem. 278, 42161 (2003)
- Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein: G. Zhao, et al.; J. Biol. Chem. 279, 50647 (2004)
- Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia: A.P. Weng, et al.; Science 306, 269 (2004)
- Determination of guinea-pig cortical gamma-secretase activity ex vivo following the systemic administration of a gamma-secretase inhibitor: S. Grimwood, et al.; Neuropharmacology 48, 1002 (2005)
- Jagged/Notch signalling is required for a subset of TGFbeta1 responses in human kidney epithelial cells: K.C. Nyhan, et al.; Biochim. Biophys. Acta 1803, 1386 (2010)