Compstatin

AbMole BioScience

Compstatin

9

206645-99-0

Chemical

C66H99N23O17S2

1550.77

Compstatinis is a 13-residue cyclic peptide, binds to complement component C3 and inhibits complement activation with IC50 of 12 uM. Compstatin exhibits exclusive specificity for primate C3s and does not bind either to C3s from lower mammalian species or to two structural homologs of C3, human C4 and C5.

CCC(C)C(N)C(=O)NC1CSSCC(NC(=O)C(CCCNC(N)=N)NC(=O)C(CC2=CN=C[NH]2)NC(=O)C(CC3=CN=C[NH]3)NC(=O)CNC(=O)C(CC4=C[NH]C5=CC=CC=C45)NC(=O)C(CC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(NC1=O)C(C)C)C(C)C)C(=O)NC(C(C)O)C(N)=O

-20°C, protect from light, dry, sealed

12352200