COMT-IN-1 [2987884-27-3]

TargetMol Chemicals

COMT-IN-1 [2987884-27-3]

9

Research Use Only

C24H18FN3O6

463.42

COMT-IN-1 (compound C12) is a nitrophenol analog and an orally active catechol-O-methyltransferase (COMT) inhibitor. It exhibits IC50 values of 0.37 microM for COMT, 95.58 microM for MAO-A, and 58.82 microM for MAO-B, demonstrating its inhibitory activity on these enzymes. Additionally, COMT-IN-1 displays chelation properties with various metal ions and has good blood-brain barrier permeability. This compound enhances dopamine levels in mice and ameliorates symptoms of MPTP-induced Parkinsons disease (PD).

FC1=CC=CC(COC(C=C2)=CC=C2CNC(/C(C#N)=C/C3=CC([N+]([O-])=O)=C(C(O)=C3)O)=O)=C1

-20°C

51202000